Case historyCase history
Recent CBC/differential data from the months prior to bone marrow examinationRecent CBC/differential data from the months prior to bone marrow examination
2012 peripheral blood smear showing shift to immaturity, monocytosis and eosinophilia2012 peripheral blood smear showing shift to immaturity, monocytosis and eosinophilia
2012 bone marrow aspirate with mildly increased blasts but markedly increased eosinophils2012 bone marrow aspirate with mildly increased blasts but markedly increased eosinophils
2012 flow cytometry of bone marrow aspirate with large population of eosinophils but no evidence of previously diagnosed T lymphoblastic lymphoma2012 flow cytometry of bone marrow aspirate with large population of eosinophils but no evidence of previously diagnosed T lymphoblastic lymphoma
2012 peripheral blood smear (one week later) with similar findings2012 peripheral blood smear (one week later) with similar findings
2012 bone marrow aspirate (one week later) with fewer eosinophils but a greater number of blasts2012 bone marrow aspirate (one week later) with fewer eosinophils but a greater number of blasts
2012 bone marrow trephine biopsy (one week later) with 70% cellularity, myeloid hyperplasia, shift to immaturity and eosinophilia2012 bone marrow trephine biopsy (one week later) with 70% cellularity, myeloid hyperplasia, shift to immaturity and eosinophilia
Additional clinical information from initial presentation with T lymphoblastic lymphoma in 2009Additional clinical information from initial presentation with T lymphoblastic lymphoma in 2009
2009 touch imprint of lymph node with blasts and an eosinophil2009 touch imprint of lymph node with blasts and an eosinophil
2009 lymph node H&E with inset showing greater histologic detail2009 lymph node H&E with inset showing greater histologic detail
2009 lymph node flow cytometry results2009 lymph node flow cytometry results
2009 peripheral blood smear remarkable only for eosinophilia2009 peripheral blood smear remarkable only for eosinophilia
2009 staging bone marrow with 16% blasts (mostly hematogones) and 8% eosinophils2009 staging bone marrow with 16% blasts (mostly hematogones) and 8% eosinophils
2009 bone marrow flow cytometry with about 15% hematogones but only 3% T lymphoblasts2009 bone marrow flow cytometry with about 15% hematogones but only 3% T lymphoblasts
Karyogram showing t(7;8)(q22;p11.2), present in the lymph node and marrow in 2009, and in the marrow in 2012Karyogram showing t(7;8)(q22;p11.2), present in the lymph node and marrow in 2009, and in the marrow in 2012
FISH confirming FGFR1 rearrangementFISH confirming FGFR1 rearrangement