Peripheral blood: Typical lymphoblasts (right) and a large cell with coarse chromatin and dense blue cytoplasm (left) blast vs. lymphoma cell.Peripheral blood: Typical lymphoblasts (right) and a large cell with coarse chromatin and dense blue cytoplasm (left) blast vs. lymphoma cell.
Peripheral blood: Large blasts with fine chromatin, prominent nucleoli and moderate pale blue-grey cytoplasm with a few fine vacuoles.Peripheral blood: Large blasts with fine chromatin, prominent nucleoli and moderate pale blue-grey cytoplasm with a few fine vacuoles.
Bone marrow: Many small to intermediate-sized blasts, a few larger blasts and occasional fine cytoplasmic vacuoles.Bone marrow: Many small to intermediate-sized blasts, a few larger blasts and occasional fine cytoplasmic vacuoles.
Flow cytometry from blood: Mature B-cell phenotype positive for CD19, sCD22, sLambda-restricted, but only dim CD10. Notice dim CD45. Flow cytometry from blood: Mature B-cell phenotype positive for CD19, sCD22, sLambda-restricted, but only dim CD10. Notice dim CD45.
Flow cytometry from blood: Tumor cells are positive for CD19 and cCD22, but negative for TdT, CD34, CD117, and cCD3.Flow cytometry from blood: Tumor cells are positive for CD19 and cCD22, but negative for TdT, CD34, CD117, and cCD3.