T-lymphoblastic lymphoma (T-LBL) and myeloid neoplasm in association with the RABEP1/PDGFRB fusion. High-magnification (1000x) images of T-lymphoblasts stained with H&ET-lymphoblastic lymphoma (T-LBL) and myeloid neoplasm in association with the RABEP1/PDGFRB fusion. High-magnification (1000x) images of T-lymphoblasts stained with H&E
High-magnification (1000x) images of T-lymphoblasts stained with TdTHigh-magnification (1000x) images of T-lymphoblasts stained with TdT
Bone marrow (BM) aspirate smear with dyserythropoiesis (Wright stain, 1000x)Bone marrow (BM) aspirate smear with dyserythropoiesis (Wright stain, 1000x)
BM biopsy with dysmegakaryopoiesis (H&E, 500x)BM biopsy with dysmegakaryopoiesis (H&E, 500x)
BM biopsy with granulocytic hyperplasia and increased eosinophils (H&E, 500x)BM biopsy with granulocytic hyperplasia and increased eosinophils (H&E, 500x)
Partial karyogram (BM) with balanced translocation at 5q33 and 7p13 (arrows)Partial karyogram (BM) with balanced translocation at 5q33 and 7p13 (arrows)
Metaphase FISH (T-LBL) with PDGFRB breakapart probe showing split orange and green signals indicative of translocationMetaphase FISH (T-LBL) with PDGFRB breakapart probe showing split orange and green signals indicative of translocation
Metaphase FISH (T-LBL) with RABEP1 (RP11-457I18) labeled in green and TP53 in orange showing split RABEP1 and TP53 signals (arrows) indicative of RABEP1 translocationMetaphase FISH (T-LBL) with RABEP1 (RP11-457I18) labeled in green and TP53 in orange showing split RABEP1 and TP53 signals (arrows) indicative of RABEP1 translocation
Schematic showing location of RP11-457I18 probe in relation to RABEP1 locus (green) and adjacent TP53 locus on chromosome 17Schematic showing location of RP11-457I18 probe in relation to RABEP1 locus (green) and adjacent TP53 locus on chromosome 17