Figure 1. Morphologic findings. A-C, CML in chronic phase showing hypercellular bone marrow with left-shifted granulocytic hyperplasia, basophilia and small hypolobated megarkaryocytic proliferation (A, H&E, 200 x; B, H&E, 400x; C, Wright-Giemsa, 1000x). D-F, CML in blast phase showing hypercellular bone marrow with trilineage hypoplasia and increased promyelocytes with rare Auer rods (arrow) and strong myeloperoxidase positivity (inset) (C, H&E, 200 x; D, H&E, 400x; E, Wright-Giemsa, 1000x).Figure 1. Morphologic findings. A-C, CML in chronic phase showing hypercellular bone marrow with left-shifted granulocytic hyperplasia, basophilia and small hypolobated megarkaryocytic proliferation (A, H&E, 200 x; B, H&E, 400x; C, Wright-Giemsa, 1000x). D-F, CML in blast phase showing hypercellular bone marrow with trilineage hypoplasia and increased promyelocytes with rare Auer rods (arrow) and strong myeloperoxidase positivity (inset) (C, H&E, 200 x; D, H&E, 400x; E, Wright-Giemsa, 1000x).
Figure 2. Karyotypic and FISH results. A, Conventional cytogenetic analysis showing 46,XX,der(3)t(3;15)(q21;q15)t(15;17)(q24.1;q21.2),t(9;22)(q34;q11.2),der(15)t(3;15),del(17)(q21)[20]. B, FISH analysis showing t(9;22)(q34;q11.2)/BCR-ABL1 and t(15;17)(q24.1;q21.2)/PML-RARA within the same clone.Figure 2. Karyotypic and FISH results. A, Conventional cytogenetic analysis showing 46,XX,der(3)t(3;15)(q21;q15)t(15;17)(q24.1;q21.2),t(9;22)(q34;q11.2),der(15)t(3;15),del(17)(q21)[20]. B, FISH analysis showing t(9;22)(q34;q11.2)/BCR-ABL1 and t(15;17)(q24.1;q21.2)/PML-RARA within the same clone.