H&E-stained bone marrow core biopsy from 1996H&E-stained bone marrow core biopsy from 1996
H&E-stained section of spleen removed in 2002 showing unremarkable histomorphology with no significant extramedullarly hematopoiesis H&E-stained section of spleen removed in 2002 showing unremarkable histomorphology with no significant extramedullarly hematopoiesis
H&E-stained section of spinal mass showing undifferentiated neoplastic cells with large nuclei with prominent nucleoli, and moderate amounts of amphophilic cytoplasm. Numerous mitoses are present in the background.H&E-stained section of spinal mass showing undifferentiated neoplastic cells with large nuclei with prominent nucleoli, and moderate amounts of amphophilic cytoplasm. Numerous mitoses are present in the background.
Flow cytometry of spinal mass showing an immature population expressing CD117, CD13, and HLA-DR (red)Flow cytometry of spinal mass showing an immature population expressing CD117, CD13, and HLA-DR (red)
Immunohistochemical stain for CD43 on spinal massImmunohistochemical stain for CD43 on spinal mass
Immunohistochemical stain for CD71 on spinal massImmunohistochemical stain for CD71 on spinal mass
Immunohistochemical stain for CD33 showing positivity in subset of neoplastic cells in spinal mass Immunohistochemical stain for CD33 showing positivity in subset of neoplastic cells in spinal mass
Karyogram of spinal mass showing complex cytogenetic abnormalitiesKaryogram of spinal mass showing complex cytogenetic abnormalities
H&E-stained bone marrow core biopsy from 2012 demonstrating morphologic findings similar to those noted in original bone marrow from 1996 H&E-stained bone marrow core biopsy from 2012 demonstrating morphologic findings similar to those noted in original bone marrow from 1996