Fluorescent in situ hybridization performed on paraffin-embedded particle preparation of bone marrow #2 demonstrates the MLL breakapart in large mononuclear immature cells as well as small convoluted nuclei compatible with maturing myeloid cells.
Bone marrow 1 aspirate smear demonstrates mild erythroid dysplasia and left shifted myeloid maturation (Wright Giemsa, 40x).
Bone marrow 1 biopsy demonstrates mild hypercellularity (50-60%)and left shifted myeloid maturation (H&E, 20x).
Bone marrow 2 aspirate smear demonstrates mild erythroid dysplasia and no increase in blasts (Wright Giemsa, 40x).
Bone marrow 1 biopsy demonstrates a normocellular marrow (30-40%) with no increase in immature cells (H&E, 20x).
Bone marrow 3 aspirate smear demonstrates mild erythroid dysplasia and no increase in immature cells (Wright Giemsa, 40x).
Bone marrow 3 biopsy demonstrates incrased cellularity (60-70%) and no increase in immature cells (H&E, 20x).
Bone marrow 3 peripheral blood smear demonstrates granulocyte hypolobation and mild hypogranulation (Wright Giemsa, 40x).
Additional figure 1: Peripheral blood