Peripheral blood smear demonstrating increased monocytes and a circulating mast cell Peripheral blood smear demonstrating increased monocytes and a circulating mast cell
Wright-stained bone marrow aspirate smear showing increased mast cells and blastsWright-stained bone marrow aspirate smear showing increased mast cells and blasts
H&E-stained bone marrow trephine biopsy showing increased interstitial blasts and peri-trabecular aggregate of spindled mast cellsH&E-stained bone marrow trephine biopsy showing increased interstitial blasts and peri-trabecular aggregate of spindled mast cells
H&E-stained marrow trephine biopsy showing sheets of atypical mast cells with abundant clear cytoplasm H&E-stained marrow trephine biopsy showing sheets of atypical mast cells with abundant clear cytoplasm
Immunohistochemical stain highlighting increased CD34+ blasts adjacent to a large aggregate of mast cells Immunohistochemical stain highlighting increased CD34+ blasts adjacent to a large aggregate of mast cells
Immunohistochemical stain for CD117 highlighting mast cells and blastsImmunohistochemical stain for CD117 highlighting mast cells and blasts
Immunohistochemical stain for tryptase highlights large numbers of mast cellsImmunohistochemical stain for tryptase highlights large numbers of mast cells
Immunohistochemical stain for CD25 demonstrates aberrant co-expression of this antigen by mast cellsImmunohistochemical stain for CD25 demonstrates aberrant co-expression of this antigen by mast cells
Molecular analysis of exon 17 of KIT gene by pyrosequencing demonstrating a GAC>GTC mutation resulting in D816V Molecular analysis of exon 17 of KIT gene by pyrosequencing demonstrating a GAC>GTC mutation resulting in D816V