Figure 1. Bone marrow evaluation in 2004. A. H&E section of marrow biopsy showing hypercellular marrow with maturing trilineage hematopoiesis; B. Bone marrow aspirate smear showing increased maturing myelopoiesis and decreased erythropoiesis; C. IHC of CD34 highlighting rare CD34+ blasts.
Figure 2. Immunophenotyping by flow cytometry in 2004: ~2% blasts which are positive for CD34, CD117, CD33, CD13, CD38 and HLA-DR.
Figure 3. Bone marrow evaluation in 2011. A. H&E section of marrow biopsy showing hypercellular marrow with increased blasts; B. Bone marrow aspirate smear showing increased blasts and myeloid left shift; C. IHC of CD34 highlighting increased CD34+ blasts.
Figure 4. Composite images showing dysmyelopoiesis in marrow aspirate smear in 2011.
Figure 5. Immunophenotyping by flow cytometry in 2011: ~12% blasts which are positive for CD34, CD117, CD33, CD13, CD38 and HLA-DR.
Figure 6. Chromosomal analysis showed abnormal male karyotype: 47, XY,+8[18]/48, XY +8,+10[2].