Low-power view of the clot section with increased marrow cellularity and well-defined nodules of pale-appearing cells, which correspond to plasmacytoid dendritic cells.Low-power view of the clot section with increased marrow cellularity and well-defined nodules of pale-appearing cells, which correspond to plasmacytoid dendritic cells.
Sheets of blasts, high-power magnificationSheets of blasts, high-power magnification
Plasmacytoid dendritic cells, high-power magnificationPlasmacytoid dendritic cells, high-power magnification
Blasts and plasmacytoid dendritic cells, bone marrow aspirateBlasts and plasmacytoid dendritic cells, bone marrow aspirate
Immunohistochemical staining for CD34 highlights sheets of blasts (left half of the image). The plasmacytoid dendritic cells do not express CD34 (right half of the image)..Immunohistochemical staining for CD34 highlights sheets of blasts (left half of the image). The plasmacytoid dendritic cells do not express CD34 (right half of the image)..
Immunohistochemical staining for TdT highlights sheets of blasts (left half of the image). The plasmacytoid dendritic cells do not express TdT (right half of the image)Immunohistochemical staining for TdT highlights sheets of blasts (left half of the image). The plasmacytoid dendritic cells do not express TdT (right half of the image)
A subset of the blasts expresses CD79a, while the plasmacytoid dendritic cells are negativeA subset of the blasts expresses CD79a, while the plasmacytoid dendritic cells are negative
A subset of the blasts expresses Pax-5, while the plasmacytoid dendritic cells are negativeA subset of the blasts expresses Pax-5, while the plasmacytoid dendritic cells are negative
Immunohistochemical staining for CD123 highlights the plasmacytoid dendritic cell aggregates Immunohistochemical staining for CD123 highlights the plasmacytoid dendritic cell aggregates
Additional figure 1Additional figure 1
Additional figure 2: CD11c IHC, 400xAdditional figure 2: CD11c IHC, 400x
Additional figure 3: CD19 IHC, 400xAdditional figure 3: CD19 IHC, 400x
Additional figure 4: TCL1 IHC, 200xAdditional figure 4: TCL1 IHC, 200x