Bone marrow aspirate with eosinophils, including eosinophil precursors with basophilic granulesBone marrow aspirate with eosinophils, including eosinophil precursors with basophilic granules
Bone marrow biopsy showing a cellular bone marrow with myeloid predominance and eosinophiliaBone marrow biopsy showing a cellular bone marrow with myeloid predominance and eosinophilia
A tryptase immunostain shows only rare, unremarkable mast cellsA tryptase immunostain shows only rare, unremarkable mast cells
Tricolor fusion probe for PDGFRA abnormalities. This nucleus shows one normal 4q12 locus with a tri-color fusion, and one abnormal locus with retention of FIP1L1 (green) and PDGFRA (aqua) probes and loss of the intervening (red) probe. The findings are consistent with a FIP1L1-PDGFRA fusion.Tricolor fusion probe for PDGFRA abnormalities. This nucleus shows one normal 4q12 locus with a tri-color fusion, and one abnormal locus with retention of FIP1L1 (green) and PDGFRA (aqua) probes and loss of the intervening (red) probe. The findings are consistent with a FIP1L1-PDGFRA fusion.
SNP microarray analysis confirms a deletion of chromosome 4q12 in a small percentage of nucleiSNP microarray analysis confirms a deletion of chromosome 4q12 in a small percentage of nuclei
The deletion breakpoints are located within FIP1L1 and PDGFRA, consistent with a FIP1L1-PDGFRA fusionThe deletion breakpoints are located within FIP1L1 and PDGFRA, consistent with a FIP1L1-PDGFRA fusion
Following initiation of imatinib therapy, the eosinophil counts rapidly corrected to within the normal rangeFollowing initiation of imatinib therapy, the eosinophil counts rapidly corrected to within the normal range