Peripheral blood with circulating atypical large granular lymphoid cells (Wright Giemsa, 1000x)Peripheral blood with circulating atypical large granular lymphoid cells (Wright Giemsa, 1000x)
Touch preparation showing atypical large granular lymphoid cell (Wright Giemsa, 1000x)Touch preparation showing atypical large granular lymphoid cell (Wright Giemsa, 1000x)
Core biopsy section showing extensive necrosis (H&E, 100x)Core biopsy section showing extensive necrosis (H&E, 100x)
Core biopsy section adjacent to necrotic area showing small clusters of atypical large lymphoid cells (H&E, 200x)Core biopsy section adjacent to necrotic area showing small clusters of atypical large lymphoid cells (H&E, 200x)
Atypical lymphoid cells staining for CD2 (Immunoperoxidase, 400x)Atypical lymphoid cells staining for CD2 (Immunoperoxidase, 400x)
Atypical lymphoid cells staining for CD3 (Immunoperoxidase, 200x)Atypical lymphoid cells staining for CD3 (Immunoperoxidase, 200x)
Atypical lymphoid cells staining for CD3 (Immunoperoxidase, 1000x)Atypical lymphoid cells staining for CD3 (Immunoperoxidase, 1000x)
Atypical lymphoid cells staining for Granzyme B (Immunoperoxidase, 400x)Atypical lymphoid cells staining for Granzyme B (Immunoperoxidase, 400x)
Atypical lymphoid cells staining for TIA-1 (Immunoperoxidase, 200x)Atypical lymphoid cells staining for TIA-1 (Immunoperoxidase, 200x)
Atypical lymphoid cells staining for EBV-EBER (In Situ Hybridization, 200x)Atypical lymphoid cells staining for EBV-EBER (In Situ Hybridization, 200x)
Atypical lymphoid cells are negative for CD56 (Immunoperoxidase, 200x)Atypical lymphoid cells are negative for CD56 (Immunoperoxidase, 200x)
Atypical lymphoid cells are negative for CD57 (Immunoperoxidase, 200x)Atypical lymphoid cells are negative for CD57 (Immunoperoxidase, 200x)
Macrophages demonstrating increased hemophagocytosis, highlighted on CD68 staining (Immunoperoxidase, 400x)Macrophages demonstrating increased hemophagocytosis, highlighted on CD68 staining (Immunoperoxidase, 400x)
Flow cytometry showing a population of atypical lymphoid cells with increased forward scatter and side scatter characteristics (green)Flow cytometry showing a population of atypical lymphoid cells with increased forward scatter and side scatter characteristics (green)
Atypical lymphoid cells are positive for CD56 and negative for surface CD3Atypical lymphoid cells are positive for CD56 and negative for surface CD3
Atypical lymphoid cells show expression of CD2 (bright) and CD7 (dim) but no expression of CD5Atypical lymphoid cells show expression of CD2 (bright) and CD7 (dim) but no expression of CD5
Atypical lymphoid cells lack CD4, CD8, and CD25Atypical lymphoid cells lack CD4, CD8, and CD25
Atypical lymphoid cells lack both TCR alpha/beta and gamma/delta as well as CD1aAtypical lymphoid cells lack both TCR alpha/beta and gamma/delta as well as CD1a
Atypical lymphoid cells show bright expression of CD16 and CD2 but lack expression of CD57Atypical lymphoid cells show bright expression of CD16 and CD2 but lack expression of CD57
Core biopsy section showing large atypical lymphoid cells with irregular nuclear borders, prominent nucleoli, and vesicular chromatin; background small lymphoid cells and erythroid precursors for size comparison (H&E 1000x)Core biopsy section showing large atypical lymphoid cells with irregular nuclear borders, prominent nucleoli, and vesicular chromatin; background small lymphoid cells and erythroid precursors for size comparison (H&E 1000x)
Chromosomal studies showing add(3)(p25), del(18)(q11.2), add(18)(q21), and add(21)(p12)Chromosomal studies showing add(3)(p25), del(18)(q11.2), add(18)(q21), and add(21)(p12)
Dual color breakapart probes for 14q11 showing polysomy (+14q)Dual color breakapart probes for 14q11 showing polysomy (+14q)
Dual color breakapart probes for 11q23 showing polysomy (+11q)Dual color breakapart probes for 11q23 showing polysomy (+11q)