Bone marrow aspirate with blasts with intermediate to large size, fine chromatin, discrete nucleoli, and scant cytoplasm. Bone marrow aspirate with blasts with intermediate to large size, fine chromatin, discrete nucleoli, and scant cytoplasm.
Bone marrow biopsy showing blasts (35%) present in a diffuse and interstitial pattern admixed with background myeloid and erythroid precursors and morphologically normal megakaryocytes. Bone marrow biopsy showing blasts (35%) present in a diffuse and interstitial pattern admixed with background myeloid and erythroid precursors and morphologically normal megakaryocytes.
FISH analysis with PDGFRB break apart probe showing separation of the fusion signal, indicating rearrangement of the PDGFRB locus. FISH analysis with PDGFRB break apart probe showing separation of the fusion signal, indicating rearrangement of the PDGFRB locus.
Conventional cytogenetics showing abnormal karyotype: 47,XY,add(5)(q31),del(5)(q13q33),+marConventional cytogenetics showing abnormal karyotype: 47,XY,add(5)(q31),del(5)(q13q33),+mar