Cytospin of bone marrow aspirate showing immature cells with intermediate to large size, irregular nuclear contours with some folded nuclei, prominent nucleoli, and granular cytoplasm, including Auer rods.Cytospin of bone marrow aspirate showing immature cells with intermediate to large size, irregular nuclear contours with some folded nuclei, prominent nucleoli, and granular cytoplasm, including Auer rods.
Myeloperoxidase cytochemical stain showing strong positive staining in the immature cells.Myeloperoxidase cytochemical stain showing strong positive staining in the immature cells.
Bone marrow biopsy showing sheets of immature cells.Bone marrow biopsy showing sheets of immature cells.
Conventional cytogenetics showing normal karyotype: 46,XXConventional cytogenetics showing normal karyotype: 46,XX
FISH for the PML/RARA fusion associated with the translocation t(15;17)(q22;q21) was negative for the typical fusion as well as abnormal patterns.FISH for the PML/RARA fusion associated with the translocation t(15;17)(q22;q21) was negative for the typical fusion as well as abnormal patterns.
RT-PCR positive for transcripts associated with the Bcr1 form PML-RARA translocationRT-PCR positive for transcripts associated with the Bcr1 form PML-RARA translocation