Right parotid tail lymph node, excisional biopsy, H&E, 2x: H&E sections show that the overall lymph node architecture is intact. Interfollicular zones harbor some prominent vessels.Right parotid tail lymph node, excisional biopsy, H&E, 2x: H&E sections show that the overall lymph node architecture is intact. Interfollicular zones harbor some prominent vessels.
Right parotid tail lymph node, excisional biopsy, H&E, 4x: Scattered germinal centers appear expanded, while others are somewhat atrophic. Well-developed features of Castleman disease are not identified. Right parotid tail lymph node, excisional biopsy, H&E, 4x: Scattered germinal centers appear expanded, while others are somewhat atrophic. Well-developed features of Castleman disease are not identified.
Right parotid tail lymph node, excisional biopsy, H&E, 10x: Clusters of atypical medium-to-large cells can be seen in a germinal center-based distribution. These cells are not identified in the surrounding interfollicular zones. Right parotid tail lymph node, excisional biopsy, H&E, 10x: Clusters of atypical medium-to-large cells can be seen in a germinal center-based distribution. These cells are not identified in the surrounding interfollicular zones.
Right parotid tail lymph node, excisional biopsy, H&E, 20x: These atypical cells resemble immunoblasts or plasmablasts.Right parotid tail lymph node, excisional biopsy, H&E, 20x: These atypical cells resemble immunoblasts or plasmablasts.
Right parotid tail lymph node, excisional biopsy, H&E, 40x: Cytologically, the atypical cells have abundant eosinophilic cytoplasm, large round-to-oval nuclei with irregular nuclear borders, vesicular chromatin, and variably prominent nucleoli.Right parotid tail lymph node, excisional biopsy, H&E, 40x: Cytologically, the atypical cells have abundant eosinophilic cytoplasm, large round-to-oval nuclei with irregular nuclear borders, vesicular chromatin, and variably prominent nucleoli.
Right parotid tail lymph node, excisional biopsy, H&E, 40x: Some of the atypical cells have bizarre nuclear features including multilobation and intranuclear inclusions.Right parotid tail lymph node, excisional biopsy, H&E, 40x: Some of the atypical cells have bizarre nuclear features including multilobation and intranuclear inclusions.
Right parotid tail lymph node, excisional biopsy, H&E, 40x: Mitotic figures are easily identified in the germinal center-based atypical cells.Right parotid tail lymph node, excisional biopsy, H&E, 40x: Mitotic figures are easily identified in the germinal center-based atypical cells.
CD45, 20x: The atypical cells are weakly positive for CD45.CD45, 20x: The atypical cells are weakly positive for CD45.
CD43, 20x: The atypical cells are largely negative for CD43.CD43, 20x: The atypical cells are largely negative for CD43.
CD20, 20x: The atypical cells are dimly positive for CD20.CD20, 20x: The atypical cells are dimly positive for CD20.
CD3, 20x: The atypical cells are negative for CD3. CD3, 20x: The atypical cells are negative for CD3.
CD30, 20x: CD30 is negative in the atypical cells. CD30, 20x: CD30 is negative in the atypical cells.
CD138, 20x: CD138 is negative in the atypical cells. CD138, 20x: CD138 is negative in the atypical cells.
MUM-1, 20x: MUM-1 is uniformly positive in the atypical cells.MUM-1, 20x: MUM-1 is uniformly positive in the atypical cells.
Ki-67, 20x: The atypical cells show a high proliferative index by Ki-67.Ki-67, 20x: The atypical cells show a high proliferative index by Ki-67.
HHV-8, 20x: The atypical cells are uniformly positive for HHV-8. HHV-8, 20x: The atypical cells are uniformly positive for HHV-8.
EBER-ISH, 20x: The atypical cells are uniformly positive for EBV (by EBER-ISH).EBER-ISH, 20x: The atypical cells are uniformly positive for EBV (by EBER-ISH).
Kappa, 20x: Kappa highlights rare background plasma cells, but is mostly negative in the cells of interest. Kappa, 20x: Kappa highlights rare background plasma cells, but is mostly negative in the cells of interest.
Lambda, 20x: Lambda highlights rare background plasma cells, but is mostly negative in the cells of interest.Lambda, 20x: Lambda highlights rare background plasma cells, but is mostly negative in the cells of interest.