Representative cells in peripheral blood: a normal sized blast, mature granulocyte and mature monocyte (top panel L-R). In comparison giant blast, granulocyte, and monocyte (lower panel L-R) likely from the tetraploid clone.Representative cells in peripheral blood: a normal sized blast, mature granulocyte and mature monocyte (top panel L-R). In comparison giant blast, granulocyte, and monocyte (lower panel L-R) likely from the tetraploid clone.
Bone marrow core biopsy and touch preparation. (A) The biopsy shows sheets of large irregular blasts with folded nuclei and a monocytic appearance. (B) Representative blasts from touch preparation.Bone marrow core biopsy and touch preparation. (A) The biopsy shows sheets of large irregular blasts with folded nuclei and a monocytic appearance. (B) Representative blasts from touch preparation.
Combined esterase reaction [alpha naphthyl butyrate esterase (ANB), orange brown; chloroacetate esterase (CAE), blue]: Numerous monocytic elements identified by ANB reactivity with occasional dual positive cells.Combined esterase reaction [alpha naphthyl butyrate esterase (ANB), orange brown; chloroacetate esterase (CAE), blue]: Numerous monocytic elements identified by ANB reactivity with occasional dual positive cells.
Karyogram: The tetraploid clone with double t(8;21)(q22;q22) seen in 75% of metaphase cells is depicted.Karyogram: The tetraploid clone with double t(8;21)(q22;q22) seen in 75% of metaphase cells is depicted.