The flow cytometric analysis of this bone marrow case demonstrates that approximately 25% of events are within the immature cell/blast gate, and 67% of events are within the CD45-negative gate. Both the blast and CD45-negative populations express CD71; however, the blast population is negative for CD235a.The flow cytometric analysis of this bone marrow case demonstrates that approximately 25% of events are within the immature cell/blast gate, and 67% of events are within the CD45-negative gate. Both the blast and CD45-negative populations express CD71; however, the blast population is negative for CD235a.
The flow cytometric analysis of this bone marrow case demonstrates that the blast population expresses a dim CD33 and CD7 without expression of CD34, CD117, CD14, CD64, or TdT. The CD45-negative population does not express CD34 either.The flow cytometric analysis of this bone marrow case demonstrates that the blast population expresses a dim CD33 and CD7 without expression of CD34, CD117, CD14, CD64, or TdT. The CD45-negative population does not express CD34 either.
The flow cytometric analysis of this bone marrow demonstrates that the blast and CD45-negative populations do not significantly express MPO, cytoplasmic CD15, B lymphocyte antigens, or T lymphocyte antigens.The flow cytometric analysis of this bone marrow demonstrates that the blast and CD45-negative populations do not significantly express MPO, cytoplasmic CD15, B lymphocyte antigens, or T lymphocyte antigens.
The peripheral blood smear shows circulating blasts. (Wright-Giemsa; 1000x magnification)The peripheral blood smear shows circulating blasts. (Wright-Giemsa; 1000x magnification)
The peripheral blood smear shows circulating erythroid precursors with dyserythropoietic features. (Wright-Giemsa; 1000x magnification)The peripheral blood smear shows circulating erythroid precursors with dyserythropoietic features. (Wright-Giemsa; 1000x magnification)
The peripheral blood smear also shows neutrophils with pelgeroid morphology. (Wright-Giemsa; 1000x magnification)The peripheral blood smear also shows neutrophils with pelgeroid morphology. (Wright-Giemsa; 1000x magnification)
The bone marrow aspirate has cellular spicules. (Wright-Giemsa; 100x magnification)The bone marrow aspirate has cellular spicules. (Wright-Giemsa; 100x magnification)
The bone marrow aspirate shows a predominance of erythroid precursors with scattered blasts. (Wright-Giemsa; 500x magnification)The bone marrow aspirate shows a predominance of erythroid precursors with scattered blasts. (Wright-Giemsa; 500x magnification)
The bone marrow aspirate shows predominantly erythroid precursors with dyserythropoiesis with scattered blasts, and the myeloid lineage is decreased with dysmyelopoiesis noted. (Wright-Giemsa; 1000x magnification)The bone marrow aspirate shows predominantly erythroid precursors with dyserythropoiesis with scattered blasts, and the myeloid lineage is decreased with dysmyelopoiesis noted. (Wright-Giemsa; 1000x magnification)
The bone marrow aspirate shows a globular cytoplasmic staining pattern with PAS in erythroid progenitors. (PAS; 1000x magnification)The bone marrow aspirate shows a globular cytoplasmic staining pattern with PAS in erythroid progenitors. (PAS; 1000x magnification)
The bone marrow is hypercellular (90-95%). (H&E; 40x magnification)The bone marrow is hypercellular (90-95%). (H&E; 40x magnification)
The bone marrow core demonstrates a predominance of erythroid progenitors, scattered blasts, and scattered megakaryocytes showing dysmegakaryopoiesis. (H&E; 400x magnification)The bone marrow core demonstrates a predominance of erythroid progenitors, scattered blasts, and scattered megakaryocytes showing dysmegakaryopoiesis. (H&E; 400x magnification)
The bone marrow core demonstrates only focal immunoreactivity of erythroid progenitors for E-cadherin. (E-cadherin; 400x magnification)The bone marrow core demonstrates only focal immunoreactivity of erythroid progenitors for E-cadherin. (E-cadherin; 400x magnification)
The bone marrow core shows some immunoreactivity of more mature erythroid progenitors with hemoglobin A. (Hemoglobin A; 400x magnification)The bone marrow core shows some immunoreactivity of more mature erythroid progenitors with hemoglobin A. (Hemoglobin A; 400x magnification)