Peripheral blood 20x showing a macrocytic anemia and thrombocytosisPeripheral blood 20x showing a macrocytic anemia and thrombocytosis
Bone marrow aspirate 10x showing an increase in megakaryocytes with several monolobated formsBone marrow aspirate 10x showing an increase in megakaryocytes with several monolobated forms
Bone marrow aspirate 20x showing monolobated megakaryocytes and progressive maturation in granulocyte and erythroid precursors without distinct dyspoiesisBone marrow aspirate 20x showing monolobated megakaryocytes and progressive maturation in granulocyte and erythroid precursors without distinct dyspoiesis
Bone marrow core biopsy 10x showing increased megakaryocytes with many monolobated formsBone marrow core biopsy 10x showing increased megakaryocytes with many monolobated forms
Bone marrow core biopsy 20x showing many monolobated megakaryocytes and progressive maturation in granulocyte and erythroid precursorsBone marrow core biopsy 20x showing many monolobated megakaryocytes and progressive maturation in granulocyte and erythroid precursors
Conventional karyotype identified deletion in the long (q) arm of chromosome 5Conventional karyotype identified deletion in the long (q) arm of chromosome 5
FISH for EGR1 on chromosome 5: Normal signal on left, abnormal signal on right indicating 5q deletionFISH for EGR1 on chromosome 5: Normal signal on left, abnormal signal on right indicating 5q deletion