Bone marrow core biopsy demonstrates a hypercellular marrow with trilineage hypoplasia and markedly increased immature cells (H&E, x200). Bone marrow core biopsy demonstrates a hypercellular marrow with trilineage hypoplasia and markedly increased immature cells (H&E, x200).
Bone marrow aspirate smear shows a cluster of blasts (Gimesa, x1000).Bone marrow aspirate smear shows a cluster of blasts (Gimesa, x1000).
A representative karyotype and metaphase cell shows 46,XX,t(2;16)(p21;p11.2),t(11;14)(p13;p11.2). The arrows indicate translocations between chromosomes 2p21 and 16p11.2, and between 11p13 and 14p11.2, respectively.A representative karyotype and metaphase cell shows 46,XX,t(2;16)(p21;p11.2),t(11;14)(p13;p11.2). The arrows indicate translocations between chromosomes 2p21 and 16p11.2, and between 11p13 and 14p11.2, respectively.
Fluorescence in situ hybridization using Cytocell whole chromosome painting probe for chromosome 11 on a G-banded metaphase confirms the t(11;14), which indicates: ish t(11;14)(p13;p11.2)(wcp11+). Fluorescence in situ hybridization using Cytocell whole chromosome painting probe for chromosome 11 on a G-banded metaphase confirms the t(11;14), which indicates: ish t(11;14)(p13;p11.2)(wcp11+).