A- The core biopsy is markedly hypercellular. B-Higher power shows there are sheets of blasts. C- Aspirate smear shows blasts with basophilic granular cytoplasm, some clefted nuclei, fine chromatin, and prominent nucleoli. A- The core biopsy is markedly hypercellular.  B-Higher power shows there are sheets of blasts.  C- Aspirate smear shows blasts with basophilic granular cytoplasm, some clefted nuclei, fine chromatin, and prominent nucleoli.
A- The blasts are positive for CD34 and PAX5 (B).A- The blasts are positive for CD34 and PAX5 (B).
There are increase blasts (42%) that are positive for CD19 (partial), CD34, CD7, CD33 (dim), HLA-DR (dim), MPO (partial), and cCD79a (partial).There are increase blasts (42%) that are positive for CD19 (partial), CD34, CD7, CD33 (dim), HLA-DR (dim), MPO (partial), and cCD79a (partial).