A- The core biopsy shows a hypercellular marrow with aggregates of blasts. B- The aspirate smear shows increased blasts with dysplastic granulocytes with Pelgeroid morphology and toxic granulation (vacuolization). C- The PB smear shows the dysplastic granulocytes and occasional blasts (inset). D- CD117 highlights the blasts are positive and forming aggregates (~30% of marrow elements).A- The core biopsy shows a hypercellular marrow with aggregates of blasts. B- The aspirate smear shows increased blasts with dysplastic granulocytes with Pelgeroid morphology and toxic granulation (vacuolization). C- The PB smear shows the dysplastic granulocytes and occasional blasts (inset). D- CD117 highlights the blasts are positive and forming aggregates (~30% of marrow elements).
Increased blasts were detected by flow cytometry (D gate) that were positive for CD34, HLA-DR, CD117, CD13, and CD5 (partial).Increased blasts were detected by flow cytometry (D gate) that were positive for CD34, HLA-DR, CD117, CD13, and CD5 (partial).