Peripheral blood smear demonstrates numerous circulating blasts.
Bone marrow core biopsy demonstrates blasts arranged in sheets comprise the majority of the marrow cellularity.
Cellular marrow aspirate smear demonstrates numerous blasts similar in appearance to that seen in the peripheral blood.
Some blasts show prominent cytoplasmic pseudopodial extensions.
Marker analysis demonstrates coexpression of CD4 and CD56 within the blast population.
Marker analysis demonstrates coexpression of HLA-DR and CD123 within the blast population.
Marrow aspirate smear double esterase cytochemical stain shows positive staining of blasts with alpha napthyl acetate esterase (brown-black); blasts are negative for chlororacetate esterase (red chromogen).
Butyrate esterase cytochemical stain performed on the marrow aspirate smear demonstrates blasts are positive.
Peroxidase cytochemical stain performed on the marrow aspirate smear demonstrates blasts are negative.
: Classical cytogenetic analysis performed on the marrow aspirate demonstrates t(9;11)(p22;q23).
Cytogenetic FISH with Vysis MLL Dual Color, Break Apart Rearrangement Probe is positive.