The marrow shows increased cellularity (~60-70%). The marrow shows increased cellularity (~60-70%).
Megakaryocytes are markedly increased. Megakaryocytes are markedly increased.
M:E ratio appears decreased due to decreased granulopoiesis and slightly increased erythropoiesis. Granulopoiesis demonstrates complete maturation. Erythropoiesis demonstrates complete normoblastic maturation. M:E ratio appears decreased due to decreased granulopoiesis and slightly increased erythropoiesis. Granulopoiesis demonstrates complete maturation. Erythropoiesis demonstrates complete normoblastic maturation.
Megakaryocytes are markedly increased and atypical. Megakaryocytes are markedly increased and atypical.
Reticulin stain shows marked (3+) reticulin fibrosis.Reticulin stain shows marked (3+) reticulin fibrosis.
CD34 stains slightly increased scattered blasts. MPO demonstrates decreased granulopoiesis. Glycophorin C stains maturing erythropoiesis. CD42b shows numerous dysplastic megakaryocytes, including micromegakaryocytes.CD34 stains slightly increased scattered blasts. MPO demonstrates decreased granulopoiesis. Glycophorin C stains maturing erythropoiesis. CD42b shows numerous dysplastic megakaryocytes, including micromegakaryocytes.