Peripheral blood smear showing myelophthisic picturePeripheral blood smear showing myelophthisic picture
Low power image of bone marrow biopsy section showing diffuse infiltrate of atypical cells in a background of myxoid-appearing stroma (x40, H&E)Low power image of bone marrow biopsy section showing diffuse infiltrate of atypical cells in a background of myxoid-appearing stroma (x40, H&E)
Intermediate power image of bone marrow biopsy section showing diffuse infiltrate of atypical cells in a background of myxoid-appearing stroma (x100, H&E)Intermediate power image of bone marrow biopsy section showing diffuse infiltrate of atypical cells in a background of myxoid-appearing stroma (x100, H&E)
Intermediate power image of bone marrow biopsy section showing focal residual hematopoiesis surrounded by infiltrating atypical cells (x100, H&E)Intermediate power image of bone marrow biopsy section showing focal residual hematopoiesis surrounded by infiltrating atypical cells (x100, H&E)
Touch preparation showing extensive population of immature cells with irregular nuclei and abundant basophilic cytoplasm with vacuoles and no Auer rods (x400, Wright-Giemsa) Touch preparation showing extensive population of immature cells with irregular nuclei and abundant basophilic cytoplasm with vacuoles and no Auer rods (x400, Wright-Giemsa)
Biopsy touch preparation showing extensive population of very large immature cells with irregular or folded nuclei with adjacent more mature myeloid cells for size reference (x400, Wright-Giemsa) Biopsy touch preparation showing extensive population of very large immature cells with irregular or folded nuclei with adjacent more mature myeloid cells for size reference (x400, Wright-Giemsa)
Butyrate Esterase stained touch preparation showing strong positivity in immature cells (x400)Butyrate Esterase stained touch preparation showing strong positivity in immature cells (x400)
CD56 immunohistochemical stain highlights immature cells surrounding the sole focus of residual hematopoiesis (x100)CD56 immunohistochemical stain highlights immature cells surrounding the sole focus of residual hematopoiesis (x100)
Flow cytometry histograms showing CD33+ immature cell population with bright CD45 expression and very high side and forward scatterFlow cytometry histograms showing CD33+ immature cell population with bright CD45 expression and very high side and forward scatter
Flow cytometry histograms showing that immature cell population is negative for lymphoid markersFlow cytometry histograms showing that immature cell population is negative for lymphoid markers
Flow cytometry histograms showing immature cell population to be positive for CD11b, CD56 and dim CD16Flow cytometry histograms showing immature cell population to be positive for CD11b, CD56 and dim CD16
Flow cytometry histograms showing immature cell population is negative for CD117 and CD34 but positive for HLA-DRFlow cytometry histograms showing immature cell population is negative for CD117 and CD34 but positive for HLA-DR
Flow cytometry histograms showing that immature cell population is positive for CD13, CD64, CD14 and shows partial positivity for CD15Flow cytometry histograms showing that immature cell population is positive for CD13, CD64, CD14 and shows partial positivity for CD15
Flow cytometry histograms showing that immature cell population is positive for CD38 and negative for CD19 and CD10Flow cytometry histograms showing that immature cell population is positive for CD38 and negative for CD19 and CD10
Cytogenetics on a portion of disaggregated bone marrow biopsy showing abnormal hypertetraploid karyotype with t(1;9)(q21;q22)Cytogenetics on a portion of disaggregated bone marrow biopsy showing abnormal hypertetraploid karyotype with t(1;9)(q21;q22)