Figure 1. Peripheral blood. Blasts demonstrate monocytic features (100x).
Figure 2. Peripheral blood. Neutrophils demonstrate dysplasia (100x).
Figure 3. Bone marrow touch preparation. Blasts are seen amid megakaryocytic and myeloid dysplasia (100x).
Figure 4. Bone marrow biopsy. Blasts are seen amid megakaryotic dyslasia (100x).
Figure 5. Karyotype. Reciprocal translocation between chromosome 4q12 and 12p13, resulting in fusion of PDGFRα and ETV6, and deletion of 5q.
Figure 6a. 4q12 FISH probe. Map of the Abbott Molecular-Vysis SCFD2-LNX- PDGFRA tri-color, break-apart probe for the 4q12 region.
Figure 6b. 4q12 FISH probe. Tri-color, break-apart probe for the 4q12 region demonstrated PDGFRα rearrangement, represented by separation of acqua from green and orange.
Figure 7a. 12p13 FISH probe. Map of the Abbott Molecular-Vysis ETV6 dual-color, break-apart probe for the 12p13 region .
Figure 7b. 12p13 FISH probe. Dual-color, break-apart probe for the 12p13 region demonstrated ETV6 rearrangement , represented by separation of green from orange.